Between 2003 and 2017, there were nearly 35.2 million natural deaths. In 2003, 905,874 deaths occurred in hospitals (39.7%), decreasing to 764,424 (29.8%) in 2017, while nursing facility deaths reduced from 538,817 (23.6%) to 534,714 (20.8%). Home deaths increased from 543,874 (23.8%) in 2003 to 788,757 (30.7%) in 2017, while hospice facility deaths increased from 5395 (0.2%) to 212,652 (8.3%) by 2017. Younger patients, females, and racial/ethnic minorities had reduced odds of home death compared to older patients, males and whites. Cancer patients had the greatest odds of home and hospice facility deaths and the lowest odds of nursing facility death relative to other conditions. Relative to other conditions, dementia patients had the greatest odds of nursing facility death, and respiratory disease patients had the greatest odds of hospital death. Stroke patients had the lowest odds of home death, and cardiovascular disease patients had the lowest odds of hospice facility death, relative to other conditions.