Allostatic Load and Cardiometabolic Health in a Rural Population
Allostatic load occurs when dynamic physiological set points become chronically dysregulated as the body incurs sustained stressors. Under chronic stress, multiple systems (neuroendocrine, immune, metabolic) respond to frequent activation that can eventually lead to cumulative inadequate response. A high allostatic load could function as an early warning indicator for potential adverse health outcomes, with allostatic load markers signaling the accumulation of physiological dysregulation prior to a clinical diagnosis.