Vadim N. Gladyshev, Professor of Medicine at Brigham and Women's Hospital, Harvard Medical School, presents, "Systems Aging and Rejuvenation."
What is aging? When does it begin? How to control lifespan? Can we rejuvenate organisms in addition to slowing down the aging process? There is no consensus, but recent developments in the field allow to begin answering these questions. In particular, DNA methylation of defined sets of CpG dinucleotides emerged as a critical and precise biomarker of the aging process. Multi-variate machine learning models, known as epigenetic clocks, can exploit quantitative changes in the methylome to predict the age of bulk tissue with remarkable accuracy. The first epigenetic aging clock that works at the level of single cells has also been recently developed. Together with advances in genomics and intervention strategies, these tools support accurate quantification and manipulation of the aging process. Additional topics to be covered in the talk will include development and application of molecular signatures of longevity and research on different types of rejuvenation.
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